KGW reports 16-year-old Malia Jenae Carbaugh left her home Thursday.
Carbaugh has run away before. In July, she was found in Los Angeles during a sex trafficking investigation.
Her alleged pimp, 25-year-old Damarr Jackson, was arrested for human trafficking of a minior.
Jackson, who lives in Las Vegas, is now out on bail.
Police said Carbaugh got a plane ticket from Portland to Las Vegas.
Anyone with information is asked to call Portland police at 971-563-7545.